Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.97 |
| ▸ | MPEG1 | Q2M385 | 11/20 | 0.97 |
| ▸ | XIAP | P98170 | 5/20 | 0.97 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | PTGES | O14684 | 1/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.97 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Embelin SCHEMBL148744 | 0.98 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL12757276 | 0.98 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84KDM4E | |
| Rapanone SCHEMBL2311835 | 0.98 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84KDM4E | |
| Embelin SCHEMBL4653231 | 0.92 | ALOX5 (0.88) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL9580649 | 0.89 | ALOX5 (0.83) | ALOX5MPEG1XIAPGPR84KDM4E | |
| Embelin SCHEMBL21905447 | 0.88 | ALOX5 (0.81) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL12830675 | 0.87 | ALOX5 (0.74) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL17123718 | 0.83 | ALOX5 (0.73) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL19236537 | 0.81 | ALOX5 (0.71) | ALOX5MPEG1XIAPGPR84KDM4E | |
| SCHEMBL1020312 | 0.80 | ALOX5 (0.65) | ALOX5MPEG1XIAPGPR84KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1274655-C | Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2006-09-13 | — | — | CN | disclosed |
| CN-1628088-A | Novel 3-aryl-2, 5-dihydroxy-1, 4-benzoquinones, process for preparing same and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2005-06-15 | — | — | CN | disclosed |
| US-20050085644-A1 | Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-04-21 | — | — | US | disclosed |
| US-20050085644-A1 | Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-04-21 | — | — | US | disclosed |
| EP-1472208-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-11-03 | — | — | EP | disclosed |
| EP-1472208-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066561-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-08-14 | — | — | WO | disclosed |
| WO-2003066561-A1 | NOVEL 3-ARYL-2,5-DIHYDROXY-1,4-BENZOQUINONE DERIVATIVES, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085644-A1 | Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same | GPR119, UGT1A1, UGT1A3 | ALOX5 1478/4885MPEG1 4822/4885XIAP 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.