Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640945 | 0.90 | NOTUM (0.53) | FFAR4NOTUMSCN9APDK2PTGES | |
| SCHEMBL641984 | 0.86 | NOTUM (0.50) | FFAR4NOTUMSCN9A | |
| SCHEMBL642235 | 0.82 | NOTUM (0.48) | FFAR4NOTUMSCN9A | |
| SCHEMBL12717115 | 0.82 | FFAR4 (0.72) | FFAR4NOTUMCHRM4CHRM2 | |
| SCHEMBL13630728 | 0.78 | NOTUM (0.58) | FFAR4NOTUMCHRM4PDK2CHRM2 | |
| SCHEMBL1817248 | 0.76 | NOTUM (0.60) | FFAR4NOTUMPDK2 | |
| SCHEMBL6498392 | 0.76 | NOTUM (0.85) | FFAR4NOTUMCHRM4PDK2CHRM2 | |
| SCHEMBL642432 | 0.76 | NOTUM (0.48) | NOTUMSCN9A | |
| SCHEMBL18825722 | 0.76 | FFAR4 (0.57) | FFAR4NOTUMCHRM4PDK2CHRM2 | |
| SCHEMBL16695371 | 0.75 | NOTUM (0.74) | FFAR4NOTUMCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119627-B2 | Heterocyclic compounds as inhibitors of 17beta-HSD3 | STERIX LIMITED (GB) | 2012-02-21 | — | — | US | disclosed |