Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641984 | 0.91 | NOTUM (0.50) | NOTUMAKR1C3SCN9AFFAR4FFAR1 | |
| SCHEMBL642432 | 0.85 | NOTUM (0.48) | NOTUMAKR1C3SCN9AALDH1A1GAA | |
| SCHEMBL641081 | 0.82 | FFAR4 (0.55) | NOTUMSCN9AFFAR4 | |
| SCHEMBL640945 | 0.82 | NOTUM (0.53) | NOTUMSCN9AKDM4EFFAR4 | |
| SCHEMBL2073107 | 0.75 | NOTUM (0.81) | NOTUMAKR1C3KDM4EFFAR4FFAR1 | |
| SCHEMBL2557442 | 0.74 | NOTUM (0.59) | NOTUMAKR1C3FFAR1 | |
| SCHEMBL1817248 | 0.72 | NOTUM (0.60) | NOTUMFFAR4 | |
| SCHEMBL12716971 | 0.72 | NEK2 (0.54) | NOTUM | |
| SCHEMBL3215648 | 0.71 | NOTUM (0.59) | NOTUMAKR1C3 | |
| SCHEMBL30755065 | 0.71 | NOTUM (0.59) | NOTUMAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119627-B2 | Heterocyclic compounds as inhibitors of 17beta-HSD3 | STERIX LIMITED (GB) | 2012-02-21 | — | — | US | disclosed |