Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641081 | 0.90 | FFAR4 (0.55) | NOTUMSCN9AFFAR4PTGESPDK2 | |
| SCHEMBL641984 | 0.86 | NOTUM (0.50) | NOTUMSCN9AFFAR4 | |
| SCHEMBL642235 | 0.82 | NOTUM (0.48) | NOTUMSCN9AFFAR4KDM4E | |
| SCHEMBL1817248 | 0.79 | NOTUM (0.60) | NOTUMSERPINE1FFAR4PDK2 | |
| SCHEMBL2071701 | 0.78 | NOTUM (0.83) | NOTUMSERPINE1FFAR4PDK2POLB | |
| SCHEMBL642432 | 0.76 | NOTUM (0.48) | NOTUMSCN9APOLB | |
| SCHEMBL31343287 | 0.76 | NOTUM (0.53) | NOTUMSERPINE1FFAR4POLBCYP2C9 | |
| SCHEMBL28751454 | 0.72 | CTNNB1 (0.59) | SCN9ACYP2C19KDM4E | |
| SCHEMBL21180892 | 0.71 | NOTUM (0.67) | NOTUMSERPINE1PDK2CYP2C9CYP2C19 | |
| SCHEMBL13630728 | 0.71 | NOTUM (0.58) | NOTUMFFAR4PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119627-B2 | Heterocyclic compounds as inhibitors of 17beta-HSD3 | STERIX LIMITED (GB) | 2012-02-21 | — | — | US | disclosed |