Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629741 | 0.86 | SIRT1 (0.65) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL6412417 | 0.83 | ALDH1A1 (0.49) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL1804941 | 0.80 | KDM4E (0.61) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL29778068 | 0.80 | KDM4E (0.61) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL1559658 | 0.79 | PARP1 (0.46) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL6405069 | 0.76 | P4HB (0.43) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL6389895 | 0.76 | KDM4E (0.57) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| Phenol SCHEMBL10721550 | 0.76 | KDM4E (0.57) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL3077375 | 0.76 | SIRT1 (0.77) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL39964 | 0.75 | KDM4E (0.52) | KDM4ETSHRALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |