Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210376 | 0.82 | GAA (0.50) | GAANPSR1AKR1B1HPGDPLA2G2A | |
| SCHEMBL6412426 | 0.76 | KDM4E (0.53) | P4HBGAAHPGDLMNASMN1; SMN2 | |
| SCHEMBL1569021 | 0.75 | LMNA (0.47) | GAANPSR1HPGDCYP2C9CYP2C19 | |
| SCHEMBL28787217 | 0.75 | APOBEC3G (0.54) | GAANPSR1AKR1B1HPGDCYP2C9 | |
| SCHEMBL299227 | 0.74 | AKR1B1 (0.68) | GAANPSR1AKR1B1HPGDMAPT | |
| SCHEMBL4655209 | 0.74 | AKR1B1 (0.68) | GAANPSR1AKR1B1HPGDMAPT | |
| SCHEMBL12090255 | 0.73 | P4HB (0.57) | P4HBGAAAKR1B1HPGDCYP2C9 | |
| SCHEMBL339508 | 0.73 | P2RX7 (0.44) | GAANPSR1MAPTMAPK1ALDH1A1 | |
| Methane SCHEMBL22289679 | 0.73 | AKR1B1 (0.65) | GAANPSR1AKR1B1HPGDMAPT | |
| SCHEMBL4100411 | 0.72 | CYP3A4 (0.48) | GAANPSR1HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |