Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10397278 | 0.74 | CSNK2A1 (0.47) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL6389902 | 0.73 | BCAT2 (0.47) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL5952738 | 0.72 | KDM4E (0.46) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL27620505 | 0.71 | TP53 (0.41) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL6406532 | 0.71 | MAPT (0.44) | ALDH1A1MAPTTSHRHSD17B10MEN1 | |
| SCHEMBL23665075 | 0.70 | ALDH1A1 (0.53) | SIRT1ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL1018603 | 0.69 | NNMT (0.47) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL29889389 | 0.69 | NNMT (0.47) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL1956878 | 0.69 | KDM4E (0.43) | ALDH1A1KDM4EMAPTHPGDTSHR | |
| SCHEMBL6937301 | 0.68 | ALDH1A1 (0.55) | SIRT1ALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |