Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463791 | 0.81 | KMT2A (0.53) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL27620505 | 0.79 | TP53 (0.41) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL2292938 | 0.74 | ESR1 (0.66) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL2679682 | 0.73 | KMT2A (0.63) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL6406534 | 0.73 | ESR1 (0.56) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL16236624 | 0.71 | KMT2A (0.47) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL27801075 | 0.71 | KMT2A (0.56) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL6412428 | 0.71 | SIRT1 (0.50) | MAPTKMT2AMEN1HSD17B10TDP1 | |
| SCHEMBL9744231 | 0.71 | MAPT (0.56) | MAPTKMT2AESR1ESR2MEN1 | |
| SCHEMBL28663041 | 0.70 | KMT2A (0.52) | MAPTKMT2AESR1ESR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050196819-A1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6887712-B1 | Methods and compositions to lower plasma cholesterol levels | ATHEROGENICS, INC. (US) | 2005-05-03 | — | — | US | disclosed |