SCHEMBL6413245

SCHEMBL6413245

Cn1c(=O)n(C)c2cc(NC3=C(Cl)C(=O)C(Nc4ccc5c(c4)n(C)c(=O)n5C)=C(Cl)C3=O)ccc21

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
SMN1; SMN2 Q16637 7/20 0.54
TP53 P04637 3/20 0.54
HSD17B10 Q99714 1/20 0.54
LMNA P02545 3/20 0.52
HTT P42858 1/20 0.52
TRIM24 O15164 4/20 0.51
BCL6 P41182 2/20 0.51
BRPF1 P55201 2/20 0.50
BRD1 O95696 1/20 0.50
PKM P14618 4/20 0.49
GAA P10253 1/20 0.49
BRD4 O60885 1/20 0.47
KMT2A Q03164 1/20 0.47
XIAP P98170 1/20 0.47
BIRC2 Q13490 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24865481 0.77 TRIM24 (0.61) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL1639467 0.76 LMNA (0.45) TP53LMNAHTTBRD4KMT2A
SCHEMBL27256654 0.75 SMN1; SMN2 (0.64) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL18423614 0.73 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL30336923 0.73 SMN1; SMN2 (0.53) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL24865065 0.73 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL24865206 0.73 SMN1; SMN2 (0.53) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL24865228 0.72 SMN1; SMN2 (0.51) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL24865365 0.72 SMN1; SMN2 (0.57) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA
SCHEMBL24865703 0.72 SMN1; SMN2 (0.51) ALDH1A1SMN1; SMN2TP53HSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1120421-B1 New triphendioxazine compounds CLARIANT FINANCE BVI LTD (VG) 2005-02-09 EP disclosed
US-6617453-B1 Preparing these triphendioxazine compounds by a cyclization step conducted in the presence of manganese dioxide and concentrated sulphuric acid. CLARIANT FINANCE (BVI) LIMITED (VG) 2003-09-09 US disclosed
EP-0911337-B1 Process for the preparation of triphendioxazine compounds CLARIANT FINANCE BVI LTD (VG) 2003-02-26 EP disclosed
US-6355795-B1 PIGMENTS POSSESSING HIGH FASTNESS TO SOLVENTS, MIGRATION AND LIGHT, WHICH HAVE GOOD THERMAL STABILITIES AND HIGH TINTING POWER AND ARE ALSO EASILY DISPERSIBLE CLARIANT FINANCE (BVI) LIMITED (BV) 2002-03-12 US disclosed
EP-1120421-A2 New triphendioxazine compounds Clariant Finance (BVI) Limited (VG) 2001-08-01 EP disclosed
EP-1120420-A2 New triphendioxazine compounds Clariant Finance (BVI) Limited (VG) 2001-08-01 EP disclosed
US-6255482-B1 PREPARING CHLORINE-CONTAINING TRIPHENDIOXAZINE COMPOUNDS USEFUL AS PIGMENTS POSSESSING HIGH FASTNESS TO SOLVENTS, MIGRATION, AND LIGHT, WHICH HAVE GOOD THERMAL STABILITIES AND HIGH TINTING POWER CLARIANT FINANCE (BVI) LIMITED (VG) 2001-07-03 US disclosed
EP-0911337-A1 New triphendioxazine compounds Clariant Finance (BVI) Limited (VG) 1999-04-28 EP disclosed