Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889 | 0.91 | FFAR1 (0.46) | FFAR1S1PR1S1PR3FFAR4LPAR1 | |
| SCHEMBL6416 | 0.91 | LPAR1 (0.40) | LIPGFFAR1S1PR1S1PR3LPAR1 | |
| SCHEMBL7241 | 0.85 | LIPG (0.44) | LIPGFFAR1FFAR4AKR1B1PPARD | |
| SCHEMBL7175 | 0.84 | LPAR1 (0.38) | S1PR1S1PR3LPAR1PPARGPPARA | |
| SCHEMBL7481 | 0.84 | LPAR1 (0.55) | S1PR1S1PR3FFAR4LPAR1NR1H4 | |
| SCHEMBL6801 | 0.83 | SMN1; SMN2 (0.46) | FFAR1S1PR1S1PR3FFAR4LPAR1 | |
| SCHEMBL7250 | 0.82 | PPARG (0.46) | S1PR1S1PR3LPAR1PPARGPPARA | |
| SCHEMBL6549 | 0.82 | FFAR4 (0.45) | FFAR1S1PR1S1PR3FFAR4LPAR1 | |
| SCHEMBL6581 | 0.81 | CHRM1 (0.40) | S1PR1S1PR3FFAR4LPAR1PPARG | |
| SCHEMBL6779 | 0.81 | LPAR1 (0.42) | S1PR1S1PR3FFAR4LPAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |