Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30413242 | 0.79 | OPRM1 (0.49) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL9558710 | 0.77 | TRPM8 (0.43) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL10594114 | 0.76 | OPRM1 (0.64) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL13822311 | 0.76 | OPRM1 (0.41) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL29549463 | 0.75 | TRPM8 (0.46) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL3639819 | 0.75 | KCNA5 (0.53) | OPRM1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL8498806 | 0.73 | TRPA1 (0.43) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL9737051 | 0.73 | TRPA1 (0.43) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL9558707 | 0.73 | KCNA5 (0.44) | OPRM1TRPM8TRPA1KCNA5EPHX1 | |
| SCHEMBL8495797 | 0.73 | OPRM1 (0.44) | OPRM1TRPM8TRPA1KCNA5EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192305-A1 | HIV inhibiting pyrimidine derivatives | ANDRIES KOENRAAD JOZEF L M (BE) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192305-A1 | HIV inhibiting pyrimidine derivatives | NR4A1, CCR5, NR4A3 | OPRM1 80/4885TRPM8 2822/4885TRPA1 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.