Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708588 | 0.88 | LMNA (0.43) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL11453560 | 0.87 | DPP4 (0.47) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL30608510 | 0.86 | DPP4 (0.50) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL9488598 | 0.86 | DPP8 (0.51) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL1257864 | 0.84 | LMNA (0.53) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL5501196 | 0.83 | TACR1 (0.44) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL9011317 | 0.82 | DPP4 (0.58) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL5576449 | 0.81 | LMNA (0.50) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL27824844 | 0.80 | LMNA (0.48) | LMNADPP4DPP8DPP9DPP7 | |
| SCHEMBL1296384 | 0.80 | LMNA (0.48) | LMNADPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077031-A1 | Novel methionine aminopeptidase-2 and uses thereof | ABBOTT LABORATORIES | 2004-04-22 | — | — | US | claimed |
| US-20050026873-A1 | Type-I methionyl aminopeptidases inhibitors in antibacterial targeting | UTAH STATE UNIVERSITY | 2005-02-03 | — | — | US | disclosed |
| US-20040077031-A1 | Novel methionine aminopeptidase-2 and uses thereof | ABBOTT LABORATORIES | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026873-A1 | Type-I methionyl aminopeptidases inhibitors in antibacterial targeting | METAP1, METAP2, DNPEP | LMNA 4719/4885DPP4 35/4885DPP8 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.