Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | SPTLC2 | O15270 | 4/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SPTLC3 | Q9NUV7 | 1/20 | 0.48 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19893016 | 0.86 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL6971216 | 0.85 | SPTLC2 (0.63) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL6973987 | 0.85 | SPTLC2 (0.71) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL4128931 | 0.84 | RAB9A (0.61) | BCHEACHEALDH1A1AVPR2AVPR1A | |
| SCHEMBL6973267 | 0.84 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL4129674 | 0.83 | TSHR (0.61) | BCHEACHEALDH1A1 | |
| SCHEMBL6979289 | 0.82 | SPTLC2 (0.71) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL6421109 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL6979035 | 0.81 | SPTLC2 (0.64) | PDE4APDE4BPDE4CPDE4DSPTLC2 | |
| SCHEMBL6978484 | 0.81 | SPTLC2 (0.66) | PDE4APDE4BPDE4CPDE4DSPTLC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287441-B1 | ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE | TAKEDA PHARMACEUTICALS CO (JP) | 2021-06-09 | — | — | EP | disclosed |
| US-10189785-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICALS COMPANY LIMITED (JP) | 2019-01-29 | — | — | US | disclosed |
| US-20180170874-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-06-21 | — | — | US | disclosed |
| EP-3287441-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-6930104-B2 | Heterocyclic derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040157850-A1 | Novel heterocyclic derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-12 | — | — | US | disclosed |
| EP-1382598-A1 | NOVEL HETEROCYCLIC DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |
| US-20030216398-A1 | Soluble beta amyloid precursor protein secretion promoters | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2003-11-20 | — | — | US | disclosed |
| EP-1283055-A1 | SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189785-B2 | Heterocyclic compound | SPTLC1, SPTLC2, NPC1 | PDE4A 3440/4885PDE4B 3091/4885PDE4C 3818/4885 |
| US-20180170874-A1 | HETEROCYCLIC COMPOUND | SPTLC1, SPTLC2, NPC1 | PDE4A 3440/4885PDE4B 3091/4885PDE4C 3818/4885 |
| US-20030216398-A1 | Soluble beta amyloid precursor protein secretion promoters | APP, BDNF, BACE1 | PDE4A 2235/4885PDE4B 2563/4885PDE4C 2811/4885 |
| US-20040157850-A1 | Novel heterocyclic derivatives | APP, BACE1, PSEN1 | PDE4A 1805/4885PDE4B 2480/4885PDE4C 2696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.