Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419564 | 0.89 | HRH3 (0.39) | PDK2HRH3GRIN2BPTGDR2NPC1 | |
| SCHEMBL6421015 | 0.89 | GRIN2B (0.38) | PDK2GRIN2BNPC1RAB9ARXRA | |
| SCHEMBL6419627 | 0.87 | HRH3 (0.35) | PDK2HRH3PTGDR2NPC1RAB9A | |
| SCHEMBL6423885 | 0.84 | PTGDR2 (0.37) | PDK2PTGDR2P2RX7 | |
| SCHEMBL6420512 | 0.84 | GRIN2B (0.40) | GRIN2BCHRM5CHRM1MAPTPOLB | |
| SCHEMBL6420101 | 0.83 | KDM4E (0.38) | NPC1RAB9AMAPT | |
| SCHEMBL6420064 | 0.82 | GRIN2B (0.38) | PDK2GRIN2BPTGDR2P2RX7CHRM5 | |
| SCHEMBL6423530 | 0.81 | PTGDR2 (0.36) | PDK2GRIN2BPTGDR2P2RX7MAPT | |
| SCHEMBL6422626 | 0.81 | PTGDR2 (0.37) | PDK2GRIN2BPTGDR2NPC1RAB9A | |
| SCHEMBL6420249 | 0.80 | PTGDR2 (0.36) | PDK2PTGDR2NPC1RAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |