Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | TGM1 | P22735 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423530 | 0.92 | PTGDR2 (0.36) | GRIN2BPDK2ALDH1A1MAPTMEN1 | |
| SCHEMBL6422824 | 0.90 | CHRM5 (0.41) | GRIN2BPDK2ALDH1A1MAPTMEN1 | |
| SCHEMBL6422626 | 0.89 | PTGDR2 (0.37) | GRIN2BPDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6422607 | 0.88 | P2RX7 (0.43) | PDK2ALDH1A1MAPTP2RX7PTGDR2 | |
| SCHEMBL6422386 | 0.87 | CD274 (0.42) | — | |
| SCHEMBL6420047 | 0.87 | PTGDR2 (0.37) | PDK2MEN1KMT2AP2RX7PTGDR2 | |
| SCHEMBL6424323 | 0.86 | P2RX7 (0.44) | PDK2MAOBP2RX7F13A1TGM2 | |
| SCHEMBL6419627 | 0.83 | HRH3 (0.35) | PDK2MAPTMEN1KMT2AP2RX7 | |
| SCHEMBL6420086 | 0.83 | KMT2A (0.35) | PDK2ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL6420512 | 0.83 | GRIN2B (0.40) | GRIN2BALDH1A1MAPTFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |