Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ME2 | P23368 | 1/20 | 0.32 |
| ▸ | ME1 | P48163 | 1/20 | 0.32 |
| ▸ | ME3 | Q16798 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419655 | 0.90 | PTGDR2 (0.37) | PTGDR2LMNANPC1RAB9AHSD17B10 | |
| SCHEMBL6420064 | 0.82 | GRIN2B (0.38) | PTGDR2PDK2P2RX7ALDH1A1KDM4E | |
| SCHEMBL6422607 | 0.80 | P2RX7 (0.43) | PTGDR2POLBPDK2P2RX7ALDH1A1 | |
| SCHEMBL6419465 | 0.80 | PDK2 (0.36) | PTGDR2NPC1RAB9APOLBPDK2 | |
| SCHEMBL6423530 | 0.79 | PTGDR2 (0.36) | PTGDR2PDK2P2RX7ALDH1A1MEN1 | |
| SCHEMBL6422626 | 0.79 | PTGDR2 (0.37) | PTGDR2LMNANPC1RAB9APDK2 | |
| SCHEMBL6420047 | 0.79 | PTGDR2 (0.37) | PTGDR2PDK2P2RX7MEN1KMT2A | |
| SCHEMBL6420512 | 0.79 | GRIN2B (0.40) | LMNAPOLBALDH1A1 | |
| SCHEMBL6423885 | 0.79 | PTGDR2 (0.37) | PTGDR2PDK2P2RX7 | |
| SCHEMBL6424323 | 0.78 | P2RX7 (0.44) | PDK2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |