Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 3/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419465 | 0.89 | PDK2 (0.36) | HRH3GRIN2BL3MBTL1RXRARXRB | |
| SCHEMBL6421015 | 0.86 | GRIN2B (0.38) | GRIN2BKMT2AMEN1L3MBTL1RXRA | |
| SCHEMBL6419627 | 0.85 | HRH3 (0.35) | HRH3KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6423885 | 0.84 | PTGDR2 (0.37) | FAAHPTGDR2PDK2 | |
| SCHEMBL6420512 | 0.82 | GRIN2B (0.40) | GRIN2BALDH1A1LMNAMAPTFAAH | |
| SCHEMBL6420101 | 0.80 | KDM4E (0.38) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL6420064 | 0.80 | GRIN2B (0.38) | GRIN2BKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6422607 | 0.80 | P2RX7 (0.43) | ALDH1A1L3MBTL1MAPTFAAHPTGDR2 | |
| SCHEMBL6423522 | 0.79 | PDK2 (0.39) | GRIN2BKMT2AMEN1PTGDR2PDK2 | |
| SCHEMBL6419294 | 0.79 | PDK2 (0.37) | ALDH1A1CYP1A2NPSR1PTGDR2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |