Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515726 | 0.92 | NPC1 (0.62) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| Bromobenzene SCHEMBL5171768 | 0.84 | L3MBTL1 (0.54) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL18437367 | 0.78 | ALDH1A1 (0.58) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL11267020 | 0.77 | NPC1 (0.57) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL9048735 | 0.77 | POLB (0.61) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL27931472 | 0.76 | ALDH1A1 (0.51) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL251992 | 0.75 | NPC1 (0.69) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL6421620 | 0.73 | MAPK8 (0.48) | NPC1ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL7038772 | 0.73 | MEN1 (0.64) | POLBNPC1ALDH1A1RAB9AMEN1 | |
| SCHEMBL1436692 | 0.73 | ALDH1A1 (0.51) | POLBNPC1ALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-B1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | ENCYSIVE PHARMACEUTICALS INC (US) | 2005-03-30 | — | — | EP | claimed |