Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515726 | 0.84 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL9048735 | 0.83 | POLB (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL18437367 | 0.81 | ALDH1A1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1436692 | 0.79 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7038772 | 0.79 | MEN1 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7206410 | 0.78 | CTNNB1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL15988694 | 0.78 | POLB (0.70) | NPC1RAB9AALDH1A1POLBMEN1 | |
| Sulfamide SCHEMBL6420737 | 0.77 | POLB (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28816497 | 0.77 | CTNNB1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| Bromobenzene SCHEMBL5171768 | 0.77 | L3MBTL1 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4251535-A | ANTIARTHRITIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |
| US-4159338-A | ANTIARTHRITIC, ANALGESIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-06-26 | — | — | US | disclosed |