Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | PER2 | O15055 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425713 | 0.86 | IDO1 (0.41) | HTR3AALDH1A1ABCB1ABCG2KDM4E | |
| SCHEMBL6423030 | 0.85 | TBXA2R (0.44) | ALDH1A1TDP1KDM4ETBXA2RPTGDR | |
| SCHEMBL6424061 | 0.85 | PTGDR2 (0.35) | HTR3AABCB1ABCG2KDM4EMEN1 | |
| SCHEMBL6421108 | 0.83 | KMT2A (0.40) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL6422583 | 0.82 | TSPO (0.35) | HTR3AABCB1ABCG2KDM4EMEN1 | |
| SCHEMBL6422708 | 0.82 | OPRL1 (0.36) | HDAC1HDAC6 | |
| SCHEMBL6422093 | 0.82 | PTGS2 (0.36) | HTR3AALDH1A1ABCB1ABCG2TDP1 | |
| SCHEMBL6422817 | 0.80 | HTR3A (0.34) | HTR3AALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL6421114 | 0.79 | TP53 (0.40) | ALDH1A1KDM4EMEN1GLAKMT2A | |
| SCHEMBL6422252 | 0.78 | GLA (0.33) | ALDH1A1KDM4EMEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |