Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425713 | 0.91 | IDO1 (0.41) | PTGDR2KDM4EMEN1KMT2AGLA | |
| SCHEMBL6421108 | 0.90 | KMT2A (0.40) | KDM4EMEN1KMT2AHSD17B10CYP3A4 | |
| SCHEMBL6422708 | 0.89 | OPRL1 (0.36) | PTGDR2IDO1HDAC6HDAC1 | |
| SCHEMBL6422583 | 0.89 | TSPO (0.35) | PTGDR2KDM4EMEN1KMT2AGLA | |
| SCHEMBL6422093 | 0.86 | PTGS2 (0.36) | KDM4EMEN1KMT2AHSD17B10ABCB1 | |
| SCHEMBL6423030 | 0.86 | TBXA2R (0.44) | KDM4EHDAC6HDAC1HDAC8TBXA2R | |
| SCHEMBL6421096 | 0.85 | HTR3A (0.35) | KDM4EMEN1KMT2AGLACASP1 | |
| SCHEMBL6421114 | 0.84 | TP53 (0.40) | KDM4EMEN1KMT2AGLAHSD17B10 | |
| SCHEMBL6422817 | 0.81 | HTR3A (0.34) | MEN1KMT2AHSD17B10HTR3AIDO1 | |
| SCHEMBL6422252 | 0.80 | GLA (0.33) | KDM4EMEN1KMT2AGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |