SCHEMBL6421177

SCHEMBL6421177

O=C(Nc1ccc(NC(=O)c2ccccc2F)c2c1C(=O)c1ccccc1C2=O)c1ccccc1F

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 2/20 0.59
CTSL P07711 1/20 0.59
PTPN1 P18031 1/20 0.59
CTSS P25774 1/20 0.59
PTPN13 Q12923 1/20 0.59
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
TDP1 Q9NUW8 2/20 0.56
HTT P42858 1/20 0.54
MMP14 P50281 1/20 0.54
LMNA P02545 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
KCNMA1 Q12791 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6425913 0.85 MAPT (0.58) PTPRCCTSLPTPN1CTSSPTPN13
SCHEMBL6420464 0.85 MEN1 (0.51) PTPRCCTSLPTPN1CTSSPTPN13
SCHEMBL6422899 0.84 MEN1 (0.50) PTPRCCTSLPTPN1CTSSPTPN13
SCHEMBL11293785 0.82 PTPRC (0.51) PTPRCCTSLPTPN1CTSSPTPN13
SCHEMBL11291969 0.82 PTPRC (0.51) PTPRCCTSLPTPN1CTSSPTPN13
SCHEMBL14355330 0.81 ALDH1A1 (0.57) MEN1KMT2AHTTMMP14LMNA
SCHEMBL6421532 0.81 CASP3 (0.65) MEN1KMT2AMMP14LMNARAB9A
SCHEMBL4585595 0.81 HTT (0.61) PTPRCHTTLMNAMAPT
SCHEMBL6420621 0.79 MEN1 (0.51) PTPRCMEN1KMT2AHTTMMP14
SCHEMBL22033363 0.79 POLB (0.66) MEN1KMT2ATDP1HTTKCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050009924-A1 Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives HUANG HSU-SHAN (TW) 2005-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009924-A1 Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives NFE2L2, NR2F2, TFAM PTPRC 3438/4885CTSL 635/4885PTPN1 3824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.