Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22508440 | 0.89 | RAB9A (0.53) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL30570885 | 0.88 | CNR2 (0.57) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL29066922 | 0.88 | CNR2 (0.57) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL10586802 | 0.84 | CNR2 (0.51) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL36018 | 0.83 | TTR (0.62) | TDP1L3MBTL1ALDH1A1SRD5A2MEN1 | |
| SCHEMBL537623 | 0.83 | CNR2 (0.60) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL10029700 | 0.83 | MAPT (0.59) | ATMTDP1L3MBTL1ALDH1A1SRD5A2 | |
| SCHEMBL21603042 | 0.83 | BCL2 (0.46) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL10029708 | 0.82 | ATM (0.61) | ATMTDP1L3MBTL1CNR2ALDH1A1 | |
| SCHEMBL2188134 | 0.82 | L3MBTL1 (0.61) | ATMTDP1L3MBTL1CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |