Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423382 | 0.96 | CHRNA7 (0.51) | CHRNA7NAMPTGPR119HTR2CNPC1 | |
| SCHEMBL6421245 | 0.93 | NAMPT (0.49) | CHRNA7NAMPTGPR119MTNR1BTERT | |
| SCHEMBL12340705 | 0.82 | NAMPT (0.43) | CHRNA7NAMPTGPR119MTNR1BKDM1A | |
| SCHEMBL9282435 | 0.82 | POLB (0.56) | CHRNA7HTR2CMTNR1BDRD3HTR1A | |
| SCHEMBL6405918 | 0.81 | MTNR1B (0.54) | NPC1RAB9AMTNR1B | |
| SCHEMBL6421803 | 0.81 | GPR119 (0.46) | NAMPTGPR119MTNR1BTERTCHRM2 | |
| SCHEMBL6425809 | 0.81 | GPR119 (0.47) | NAMPTGPR119NPC1RAB9ATERT | |
| SCHEMBL6421652 | 0.81 | GPR119 (0.47) | NAMPTGPR119NPC1RAB9AMTNR1B | |
| SCHEMBL22053182 | 0.80 | CHRNA7 (0.57) | CHRNA7HTR2CMTNR1BDRD3HTR1A | |
| SCHEMBL31011171 | 0.80 | CHRNA7 (0.57) | CHRNA7HTR2CMTNR1BDRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |