Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13128892 | 0.84 | GPR119 (0.45) | GPR119NAMPT | |
| SCHEMBL6423382 | 0.84 | CHRNA7 (0.51) | GPR119NAMPTMTNR1BNPC1RAB9A | |
| SCHEMBL6421368 | 0.81 | CHRNA7 (0.50) | GPR119NAMPTMTNR1BFNTAFNTB | |
| SCHEMBL6405918 | 0.79 | MTNR1B (0.54) | MTNR1BNPC1RAB9A | |
| SCHEMBL6421245 | 0.78 | NAMPT (0.49) | GPR119NAMPTMTNR1BFNTAFNTB | |
| SCHEMBL16175115 | 0.78 | FNTA (0.57) | GPR119FNTAFNTBNPC1RAB9A | |
| SCHEMBL6422075 | 0.78 | FNTA (0.57) | GPR119FNTAFNTBNPC1RAB9A | |
| SCHEMBL9932845 | 0.78 | FNTA (0.57) | GPR119FNTAFNTBNPC1RAB9A | |
| SCHEMBL31027976 | 0.78 | MTNR1B (0.46) | GPR119MTNR1BFNTAFNTBABL1 | |
| SCHEMBL2259511 | 0.77 | MTNR1B (0.53) | GPR119MTNR1BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| CN-1129578-C | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA (JP) | 2003-12-03 | — | — | CN | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| CN-1286683-A | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA (JP) | 2001-03-07 | — | — | CN | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |