Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423382 | 0.85 | CHRNA7 (0.51) | GPR119OPRM1TERTCHRM2CHRM4 | |
| SCHEMBL6421368 | 0.81 | CHRNA7 (0.50) | GPR119OPRM1OPRD1TERTCHRM2 | |
| SCHEMBL6421245 | 0.81 | NAMPT (0.49) | GPR119TERTCHRM2CHRM4CHRM1 | |
| SCHEMBL18703634 | 0.78 | HPGD (0.48) | GPR119KDM4EHPGD | |
| SCHEMBL6425809 | 0.77 | GPR119 (0.47) | GPR119TERTDTYMKCHRM2CHRM4 | |
| SCHEMBL6422733 | 0.76 | GPR119 (0.46) | GPR119TERTDTYMKCHRM2CHRM4 | |
| SCHEMBL6405918 | 0.75 | MTNR1B (0.54) | MTNR1BPDK4 | |
| SCHEMBL29144464 | 0.74 | OPRM1 (0.54) | GPR119POLBOPRM1OPRD1OGFRL1 | |
| SCHEMBL6421652 | 0.74 | GPR119 (0.47) | GPR119MTNR1BNAMPT | |
| SCHEMBL12340705 | 0.74 | NAMPT (0.43) | GPR119OPRM1OPRD1TERTMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |