Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.55 |
| ▸ | TK1 | P04183 | 3/20 | 0.62 |
| ▸ | TK2 | O00142 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357026 | 0.95 | TK1 (0.68) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL2357020 | 0.95 | TK1 (0.68) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL1527279 | 0.95 | TK1 (0.68) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| Phosphoric Acid SCHEMBL16053559 | 0.85 | TK1 (0.72) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| Edoxudine SCHEMBL11345587 | 0.84 | TK1 (0.78) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| Water SCHEMBL6421677 | 0.84 | POLB (0.54) | — | |
| Water SCHEMBL6421666 | 0.84 | POLB (0.54) | — | |
| SCHEMBL29184342 | 0.83 | PYGM (0.61) | TK1TK2LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL223587 | 0.83 | POLB (0.55) | — | |
| SCHEMBL223586 | 0.83 | POLB (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050147965-A1 | Compositions and methods for detecting reverse transcriptase in a sample | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2005-07-07 | — | — | US | disclosed |