Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | WRN | Q14191 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 3/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163732 | 0.80 | GSK3A (0.66) | GSK3AGSK3BKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14844624 | 0.72 | MGLL (0.56) | GSK3AGSK3BSMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL2105111 | 0.70 | P2RX4 (0.40) | — | |
| SCHEMBL5165436 | 0.66 | KAT2B (0.49) | GSK3AGSK3BKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15235653 | 0.66 | POLB (0.47) | GSK3AGSK3BKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL22152246 | 0.65 | CASP3 (0.48) | GSK3AGSK3BKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2754581 | 0.65 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2ALDH1A1HPGDPOLB | |
| SCHEMBL25412731 | 0.63 | KAT2B (0.46) | KDM4ESMN1; SMN2ALDH1A1BLMWRN | |
| SCHEMBL14086671 | 0.63 | PPARG (0.44) | KDM4ESMN1; SMN2ALDH1A1POLBCASP3 | |
| SCHEMBL6422034 | 0.63 | KAT2B (0.40) | KDM4ESMN1; SMN2ALDH1A1KAT2BPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605978-A2 | THERAPEUTIC COMPOSITIONS | Alnylam Pharmaceuticals Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080406-A2 | THERAPEUTIC COMPOSITIONS | ALNYLAM PHARMACEUTICALS (US) | 2004-09-23 | — | — | WO | disclosed |