SCHEMBL6422095

SCHEMBL6422095

CCOC(=O)CCN1CCN(C(=O)NC2(c3ccccc3)CCN(C(=O)OC(C)(C)C)CC2)CC1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 3/20 0.42
TSHR P16473 2/20 0.42
ALOX15 P16050 1/20 0.42
ATM Q13315 1/20 0.42
ACKR3 P25106 3/20 0.42
MAPT P10636 1/20 0.42
TACR1 P25103 1/20 0.42
ALDH1A1 P00352 1/20 0.41
EPHX2 P34913 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6425327 0.95 CCR5 (0.44) CCR5TSHRALOX15ATMACKR3
SCHEMBL8315664 0.86 HRH2 (0.46) MAPTALDH1A1
SCHEMBL6421681 0.84 OPRM1 (0.46) ALOX15MAPTALDH1A1
SCHEMBL6423231 0.83 KMT2A (0.51) TSHRMAPTALDH1A1
SCHEMBL7968867 0.83 HRH2 (0.46) MAPT
SCHEMBL4630124 0.81 TSHR (0.50) CCR5TSHRALOX15ATMMAPT
SCHEMBL8364745 0.81 TSHR (0.52) CCR5TSHRALOX15ATMMAPT
SCHEMBL7842690 0.79 OPRM1 (0.45) MAPT
SCHEMBL4360530 0.79 KMT2A (0.46) TSHRMAPTALDH1A1
SCHEMBL4631302 0.78 ALDH1A1 (0.60) CCR5TSHRALOX15ATMTACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077942-B1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMA INC (US) 2005-01-12 EP disclosed
US-6316445-B1 TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMACEUTICALS INC. 2001-11-13 US disclosed
EP-0946545-B1 NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES AVENTIS PHARMA INC (US) 2001-09-05 EP disclosed
EP-1077942-A1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS Aventis Pharmaceuticals Inc. (US) 2001-02-28 EP disclosed
WO-1999059972-A1 CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS AVENTIS PHARMACEUTICALS INC. (US) 1999-11-25 WO disclosed
US-5977139-A Carboxysubstituted cyclic carboxamide derivatives HOECHST MARION ROUSSEL, INC. (US) 1999-11-02 US disclosed
EP-0946545-A1 NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-06 EP disclosed
WO-1998027085-A1 NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-06-25 WO disclosed