Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 7/20 | 0.46 |
| ▸ | HRH1 | P35367 | 7/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968867 | 0.96 | HRH2 (0.46) | HRH2HRH1ADORA3HTR2AHTR7 | |
| SCHEMBL6422095 | 0.86 | CCR5 (0.42) | MAPTALDH1A1 | |
| SCHEMBL6425327 | 0.84 | CCR5 (0.44) | MAPT | |
| SCHEMBL8310177 | 0.84 | KMT2A (0.50) | MAPTALDH1A1SMN1; SMN2OPRD1OPRK1 | |
| SCHEMBL6421681 | 0.83 | OPRM1 (0.46) | HRH2HRH1OPRM1SIGMAR1MAPT | |
| SCHEMBL7842690 | 0.81 | OPRM1 (0.45) | OPRM1MAPTOPRD1OPRK1 | |
| SCHEMBL6422288 | 0.73 | OPRM1 (0.47) | OPRM1MAPTALDH1A1OPRD1OPRK1 | |
| SCHEMBL7840870 | 0.71 | TACR2 (0.47) | HRH1 | |
| SCHEMBL27463567 | 0.71 | MAPT (0.68) | MAPTALDH1A1 | |
| SCHEMBL1447090 | 0.71 | OPRD1 (0.56) | OPRM1SMN1; SMN2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946545-A1 | NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027085-A1 | NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-25 | — | — | WO | disclosed |