Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | WRN | Q14191 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422071 | 0.84 | ALPL (0.35) | ALPLMAPTWRNOPRM1HSP90AA1 | |
| SCHEMBL7122832 | 0.82 | ALPL (0.40) | ALPLMAPTWRNOPRM1LMNA | |
| SCHEMBL6423040 | 0.81 | ALPL (0.34) | ALPLMAPTWRNOPRM1BUB1 | |
| SCHEMBL6421909 | 0.81 | MAPT (0.33) | ALPLMAPTWRNBUB1 | |
| SCHEMBL6376468 | 0.73 | GCGR (0.38) | ALPLMAPTWRNOPRM1LMNA | |
| SCHEMBL8129664 | 0.73 | MAPT (0.45) | ALPLMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL7123071 | 0.71 | ALPL (0.36) | ALPLMAPTOPRM1LMNABUB1 | |
| SCHEMBL7127715 | 0.68 | ALPL (0.34) | ALPLMAPTOPRM1LMNABUB1 | |
| SCHEMBL6421617 | 0.66 | CETP (0.42) | — | |
| SCHEMBL6955568 | 0.65 | NPC1 (0.48) | MAPTLMNARAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017659-B1 | SUBSTITUTED TETRAHYDRONAPHTHALINE AND ANALOGOUS COMPOUNDS | BAYER HEALTHCARE AG (DE) | 2005-04-27 | — | — | EP | disclosed |
| EP-1017659-A1 | SUBSTITUTED TETRAHYDRONAPHTHALINE AND ANALOGOUS COMPOUNDS | BAYER AG (DE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999014174-A1 | SUBSTITUTED TETRAHYDRONAPHTHALINE AND ANALOGOUS COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-03-25 | — | — | WO | disclosed |