Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421909 | 0.85 | MAPT (0.33) | ALPLMAPTBUB1 | |
| SCHEMBL7123071 | 0.85 | ALPL (0.36) | ALPLALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL7122832 | 0.80 | ALPL (0.40) | ALPLALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6376468 | 0.77 | GCGR (0.38) | ALPLALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6422071 | 0.72 | ALPL (0.35) | ALPLALDH1A1MAPTBUB1SLC6A3 | |
| SCHEMBL18863342 | 0.69 | SLC6A4 (0.38) | ALDH1A1MEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL6484099 | 0.69 | CYP1A2 (0.48) | ALPLALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6422907 | 0.68 | ALPL (0.39) | ALPLALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6423040 | 0.62 | ALPL (0.34) | ALPLMEN1KMT2AMAPTBUB1 | |
| SCHEMBL22952259 | 0.60 | KDM4E (0.47) | ALDH1A1MAPTLMNASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586613-B1 | Compounds such as 5-(tert-butyldimethylsiloxy)-7,7-dimethyl -4(4-fluorophenyl)-3-(hydroxy-(4-trifluorophenyl)-methyl)-2-isopropyl -5,6,7,8-tetrahydronaphthalene, used as antagonists for cholesteryl ester transferase protein; hyperlipemia | BAYER AKTIENGELLSCHAFT (DE) | 2003-07-01 | — | — | US | disclosed |