Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.61 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.61 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.61 |
| ▸ | PNMT | P11086 | 3/20 | 0.58 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723812 | 0.76 | CYP3A4 (0.55) | TPSAB1TPSD1TPSG1PNMTF10 | |
| SCHEMBL977949 | 0.75 | PNMT (0.73) | TPSAB1TPSD1TPSG1PNMTF10 | |
| Hydrochloric Acid SCHEMBL3088740 | 0.75 | CYP3A4 (0.54) | TPSAB1TPSD1TPSG1PNMTF10 | |
| SCHEMBL4437356 | 0.75 | F10 (0.53) | F10HPGDALDH1A1L3MBTL1KMT2A | |
| SCHEMBL19086247 | 0.74 | L3MBTL1 (0.48) | TPSAB1TPSD1TPSG1HPGDALDH1A1 | |
| SCHEMBL6421837 | 0.74 | PNMT (1.00) | TPSAB1TPSD1TPSG1PNMTF10 | |
| Hydrochloric Acid SCHEMBL3441470 | 0.74 | PNMT (0.71) | TPSAB1TPSD1TPSG1PNMTF10 | |
| SCHEMBL2370161 | 0.73 | PNMT (0.53) | TPSAB1TPSD1TPSG1PNMT | |
| SCHEMBL1075956 | 0.72 | PKM (0.52) | F10HPGDL3MBTL1KMT2APOLB | |
| SCHEMBL28533972 | 0.71 | PNMT (0.70) | TPSAB1TPSD1TPSG1PNMTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |