Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428613 | 0.91 | AKR1C3 (0.39) | ALDH1A1NOTUMAKR1C3AKR1C2SMN1; SMN2 | |
| SCHEMBL6423917 | 0.90 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1NOTUMAKR1C3AKR1C2 | |
| SCHEMBL6422846 | 0.89 | AKR1C3 (0.43) | AKR1C3AKR1C2RAB9AMEN1KMT2A | |
| SCHEMBL6425340 | 0.89 | MEN1 (0.36) | AKR1C3AKR1C2MEN1KMT2AABCB1 | |
| SCHEMBL6423401 | 0.88 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1NOTUMAKR1C3AKR1C2 | |
| SCHEMBL6422614 | 0.88 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1NOTUMAKR1C3AKR1C2 | |
| SCHEMBL6423901 | 0.88 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1NOTUMAKR1C3AKR1C2 | |
| SCHEMBL6426830 | 0.88 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1NOTUMAKR1C3AKR1C2 | |
| SCHEMBL6422809 | 0.87 | HPGD (0.34) | ALDH1A1NOTUMAKR1C3AKR1C2SMN1; SMN2 | |
| SCHEMBL6460948 | 0.87 | RORC (0.34) | NOTUMAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | ALDH1A1 630/4885L3MBTL1 4595/4885NOTUM 928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.