Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | SMO | Q99835 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27227674 | 0.86 | CXCR3 (0.49) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL27227657 | 0.86 | MBTD1 (0.53) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL30658416 | 0.86 | MBTD1 (0.53) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL30658348 | 0.83 | CXCR3 (0.55) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL27227668 | 0.83 | CXCR3 (0.55) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL30014821 | 0.81 | CXCR3 (0.50) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL27227659 | 0.81 | CXCR3 (0.50) | CXCR3ACHEDRD2DRD4DRD3 | |
| SCHEMBL28286738 | 0.81 | SLC18A3 (0.61) | CXCR3SMO | |
| SCHEMBL23535598 | 0.80 | SLC18A3 (0.64) | ACHEPRMT5WDR77SIGMAR1 | |
| SCHEMBL23535599 | 0.80 | SLC18A3 (0.64) | ACHEPRMT5WDR77SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |