Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665401 | 0.74 | MAOA (0.50) | MAOBMAOAHDAC4OPRL1 | |
| SCHEMBL5715764 | 0.72 | MAOB (0.38) | MAOBMAOAHDAC4HTR2AHTR2C | |
| SCHEMBL28919330 | 0.71 | MAOB (0.36) | MAOBMAOAHDAC4HTR2AHTR2C | |
| SCHEMBL4599737 | 0.71 | OPRM1 (0.40) | MAOBMAOAHDAC4OPRM1OPRK1 | |
| SCHEMBL8147277 | 0.69 | MAOB (0.35) | MAOBMAOAHDAC4HTR2AHTR2C | |
| SCHEMBL19717526 | 0.69 | MAOB (0.62) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL19992871 | 0.69 | MAOB (0.48) | MAOBMAOAOPRM1OPRK1OPRL1 | |
| SCHEMBL15103023 | 0.68 | MAOB (0.38) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL13562892 | 0.67 | MAOB (0.48) | MAOBMAOAHTR2AHTR2CHTR2B | |
| SCHEMBL1610186 | 0.67 | OPRM1 (0.42) | MAOBMAOAHDAC4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007614-A1 | MONOAMINE OXIDASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 6011 (US) | 2005-01-27 | — | — | WO | disclosed |