Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10004175 | 0.75 | HTR6 (0.53) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL7997494 | 0.72 | OPRM1 (0.34) | HTR6DRD2KDM4EALDH1A1MCOLN3 | |
| SCHEMBL21823899 | 0.71 | SLC1A3 (0.47) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL1898211 | 0.70 | HTR6 (0.56) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL4457178 | 0.68 | HTR6 (0.52) | HTR6ALDH1A1L3MBTL1 | |
| SCHEMBL2137879 | 0.67 | SLC1A3 (0.46) | HTR6SLC1A3SLC1A2SLC1A1KDM4E | |
| SCHEMBL2137878 | 0.67 | SLC1A3 (0.46) | HTR6SLC1A3SLC1A2SLC1A1KDM4E | |
| SCHEMBL6426729 | 0.67 | HTR6 (0.47) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL18248238 | 0.67 | RIPK1 (0.61) | HTR6SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL18936885 | 0.67 | HTR6 (0.48) | HTR6SLC1A3SLC1A2SLC1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | disclosed |