SCHEMBL6426786

SCHEMBL6426786

O=C1C(c2ccc(Cl)cc2)=C(C(F)(F)F)C(=O)N1Cc1ccc(F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.46
THRB P10828 1/20 0.46
NR1H2 P55055 2/20 0.43
NR1H3 Q13133 2/20 0.43
ALDH1A1 P00352 1/20 0.43
HTT P42858 1/20 0.43
CASP3 P42574 1/20 0.43
KMT2A Q03164 1/20 0.41
CHRM5 P08912 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 1/20 0.39
RGS4 P49798 1/20 0.39
RGS8 P57771 1/20 0.39
LMNA P02545 2/20 0.38
TP53 P04637 1/20 0.38
ADORA2A P29274 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CES2 O00748 1/20 0.37
BCHE P06276 1/20 0.37
CES1 P23141 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6427122 0.94 NR1H2 (0.47) MAPTTHRBNR1H2NR1H3ALDH1A1
SCHEMBL6426703 0.88 NR1H2 (0.41) MAPTTHRBNR1H2NR1H3ALDH1A1
SCHEMBL6428548 0.88 NR1H2 (0.56) MAPTNR1H2NR1H3ALDH1A1CASP3
SCHEMBL6427820 0.83 KMT2A (0.47) MAPTNR1H2NR1H3ALDH1A1HTT
SCHEMBL6426845 0.83 MAPT (0.50) MAPTTHRBNR1H2NR1H3ALDH1A1
SCHEMBL6430888 0.80 PKM (0.52) MAPTALDH1A1HTTKMT2ACHRM5
SCHEMBL6463014 0.78 CMA1 (0.51) MAPTNR1H2NR1H3ALDH1A1HTT
SCHEMBL6428843 0.75 NR1H2 (0.52) MAPTNR1H2NR1H3ALDH1A1KMT2A
SCHEMBL5235803 0.73 CYP1A2 (0.51) MAPTTHRBALDH1A1HTTCASP3
SCHEMBL15437830 0.73 CASP3 (0.59) NR1H2NR1H3ALDH1A1CASP3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005024755-A2 MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES DECIPHERA PHARMACEUTICALS, LLC. (US) 2005-03-17 WO disclosed