Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423936 | 0.95 | ABCB11 (0.35) | TSHRABCB11AKR1C3AKR1C2HSP90AA1 | |
| SCHEMBL6462995 | 0.94 | AKR1C3 (0.33) | TSHRABCB11AKR1C3AKR1C2HSP90AA1 | |
| SCHEMBL6425861 | 0.91 | ABCB11 (0.36) | TSHRABCB11AKR1C3AKR1C2HSP90AA1 | |
| SCHEMBL6424492 | 0.90 | AKR1C3 (0.41) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6426836 | 0.89 | TSHR (0.37) | TSHRAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6424521 | 0.89 | HSP90AA1 (0.34) | AKR1C3AKR1C2HSP90AA1HSP90AB1PTGS2 | |
| SCHEMBL6425334 | 0.89 | ALDH1A1 (0.36) | AKR1C3AKR1C2HSP90AA1HSP90AB1PTGS2 | |
| SCHEMBL6463238 | 0.88 | AKR1C3 (0.34) | ABCB11AKR1C3AKR1C2HSP90AA1HSP90AB1 | |
| SCHEMBL6423494 | 0.86 | AKR1C3 (0.39) | TSHRAKR1C3AKR1C2HSP90AA1HSP90AB1 | |
| SCHEMBL6424868 | 0.85 | ABCB11 (0.36) | TSHRABCB11AKR1C3AKR1C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | TSHR 3525/4885ABCB11 4380/4885AKR1C3 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.