SCHEMBL6427922

SCHEMBL6427922

O=C1C(=O)C2C=CC=CC2=Cc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
BCHE P06276 1/20 0.38
POLB P06746 1/20 0.38
PTPRC P08575 1/20 0.38
THRB P10828 1/20 0.38
PKM P14618 1/20 0.38
IDO1 P14902 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
PTPN1 P18031 1/20 0.38
ACHE P22303 1/20 0.38
CES1 P23141 1/20 0.38
RECQL P46063 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PTPN22 Q9Y2R2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL989079 0.77 IDO1 (0.39) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL1664032 0.72 HTR6 (0.32)
SCHEMBL342296 0.70 ANPEP (0.38) ACHE
SCHEMBL5531635 0.70 TNKS2 (0.36) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL11782467 0.70 S100A4 (0.34) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL7538817 0.67 ACHE (0.38) ALDH1A1ACHECES1
SCHEMBL5241108 0.65
SCHEMBL28300002 0.63 SLC2A1 (0.55) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL5803238 0.62 MAPT (0.39) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL3444897 0.62 CDC25B (0.57) MEN1KMT2AMAPTKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1592716-A2 METHOD OF PREPARING MOULDED ARTICLES BY MEANS OF PHOTOPOLYMERISATION IN VISIBLE OR NEAR-ULTRAVIOLET LIGHT ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2005-11-09 EP disclosed
WO-2004070427-A2 METHOD OF PREPARING MOULDED ARTICLES BY MEANS OF PHOTOPOLYMERISATION IN VISIBLE OR NEAR-ULTRAVIOLET LIGHT ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2004-08-19 WO disclosed