Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428843 | 0.80 | NR1H2 (0.52) | NR1H2NR1H3LMNAMAPTMEN1 | |
| SCHEMBL6426484 | 0.76 | APAF1 (0.52) | NR1H2NR1H3MAPTMEN1KMT2A | |
| SCHEMBL6428883 | 0.75 | NR1H2 (0.48) | NR1H2NR1H3LMNAMAPTMEN1 | |
| SCHEMBL6427927 | 0.74 | MAPT (0.52) | NR1H2NR1H3LMNAMAPTMEN1 | |
| SCHEMBL6426845 | 0.73 | MAPT (0.50) | NR1H2NR1H3LMNAMAPTRAB9A | |
| SCHEMBL6427000 | 0.73 | NR1H2 (0.60) | NR1H2NR1H3LMNAMAPTMEN1 | |
| SCHEMBL6429372 | 0.71 | SMN1; SMN2 (0.57) | LMNAMAPTABCB11KMT2A | |
| SCHEMBL23297338 | 0.70 | PDE4A (0.45) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL29776801 | 0.70 | PDE4A (0.45) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL6429547 | 0.70 | CMA1 (0.54) | NR1H2NR1H3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024755-A2 | MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2005-03-17 | — | — | WO | disclosed |