Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 1/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430888 | 0.85 | PKM (0.52) | SMN1; SMN2PKMTSHRKMT2ACMA1 | |
| SCHEMBL6428843 | 0.83 | NR1H2 (0.52) | KMT2ASCN9ALMNAALDH1A1MAPK1 | |
| SCHEMBL6426484 | 0.79 | APAF1 (0.52) | TSHRKMT2AGAAALDH1A1HSP90B1 | |
| SCHEMBL6428883 | 0.77 | NR1H2 (0.48) | SMN1; SMN2KMT2AHPGDLMNAALDH1A1 | |
| SCHEMBL6427927 | 0.77 | MAPT (0.52) | SMN1; SMN2KMT2AHPGDGAALMNA | |
| SCHEMBL6427000 | 0.76 | NR1H2 (0.60) | SMN1; SMN2KMT2ASCN9AHPGDLMNA | |
| SCHEMBL6426845 | 0.76 | MAPT (0.50) | PKMKMT2AHPGDLMNAALDH1A1 | |
| SCHEMBL19500873 | 0.73 | KMT2A (1.00) | SMN1; SMN2PKMTSHRKMT2ACMA1 | |
| SCHEMBL6429547 | 0.73 | CMA1 (0.54) | KMT2ACMA1SCN9AALDH1A1MAPT | |
| SCHEMBL1080694 | 0.71 | CMA1 (0.76) | SMN1; SMN2PKMTSHRKMT2ACMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024755-A2 | MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2005-03-17 | — | — | WO | disclosed |