Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429753 | 0.97 | PLAU (0.60) | PLAUPOLBHSPD1PTPN2PTPN1 | |
| SCHEMBL6427777 | 0.89 | PLAU (0.66) | PLAUPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6078109 | 0.89 | PLAU (0.72) | PLAUPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6428846 | 0.86 | PRMT1 (0.49) | PLAUPOLBHSPD1PTPN2PTPN1 | |
| SCHEMBL6079320 | 0.86 | PLAU (0.73) | PLAUPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL7663907 | 0.84 | MEN1 (0.58) | PLAUPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL6078762 | 0.82 | MEN1 (0.58) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL6429656 | 0.82 | ALDH1A1 (0.56) | POLBPTPN5ALDH1A1MEN1KMT2A | |
| SCHEMBL7966502 | 0.81 | ALDH1A1 (0.67) | PLAUPTPN5ALDH1A1MEN1KMT2A | |
| SCHEMBL6078632 | 0.81 | GAA (0.60) | POLBALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | claimed |
| EP-1181271-A2 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | Telik, Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000071506-A2 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK, INC. (US) | 2000-11-30 | — | — | WO | disclosed |