Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428233 | 0.98 | HSD11B1 (0.34) | ALDH1A1HSD11B1HPGDPGRTSHR | |
| SCHEMBL6464703 | 0.94 | PDE2A (0.34) | HSD11B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6460409 | 0.92 | PDE2A (0.34) | HSD11B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6428282 | 0.90 | AKR1C3 (0.39) | CYP1A2CYP2D6ABCB11AKR1C3AKR1C2 | |
| SCHEMBL6424162 | 0.89 | TSHR (0.35) | ALDH1A1HSD11B1HPGDPGRTSHR | |
| SCHEMBL6426851 | 0.89 | MEN1 (0.33) | HSD11B1PGRAKR1C3AKR1C2TAS1R3 | |
| SCHEMBL6426874 | 0.89 | ALDH1A1 (0.37) | ALDH1A1HSD11B1HPGDCYP2D6CYP2C19 | |
| SCHEMBL6425722 | 0.88 | AKR1C3 (0.39) | CYP1A2CYP2D6ABCB11AKR1C3AKR1C2 | |
| SCHEMBL6423663 | 0.88 | HSD11B1 (0.34) | ALDH1A1HSD11B1HPGDPGRTSHR | |
| SCHEMBL6424325 | 0.87 | MEN1 (0.33) | HSD11B1PGRAKR1C3AKR1C2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | ALDH1A1 630/4885HSD11B1 1120/4885HPGD 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.