Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428226 | 0.98 | TSHR (0.34) | TSHRABCB11HSD11B1AKR1C3AKR1C2 | |
| SCHEMBL6460405 | 0.94 | AKR1C3 (0.33) | AKR1C3AKR1C2APPPSEN1PSEN2 | |
| SCHEMBL6464700 | 0.92 | PTGS2 (0.33) | AKR1C3AKR1C2APPPSEN1PSEN2 | |
| SCHEMBL6425717 | 0.90 | AKR1C3 (0.40) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6423656 | 0.90 | TSHR (0.34) | TSHRHSD11B1HPGDAPPPSEN1 | |
| SCHEMBL6424324 | 0.90 | MEN1 (0.32) | HSD11B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6428281 | 0.89 | AKR1C3 (0.40) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6424159 | 0.88 | TSHR (0.34) | TSHRHSD11B1HPGDALDH1A1 | |
| SCHEMBL6426850 | 0.88 | USP30 (0.33) | HSD11B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL5560521 | 0.87 | ABCB11 (0.37) | TSHRABCB11AKR1C3AKR1C2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | TSHR 3525/4885ABCB11 4380/4885HSD11B1 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.