Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083049 | 0.84 | CASP6 (0.44) | TDP1TSHRGPR35CASP6LMNA | |
| SCHEMBL3264461 | 0.82 | PARP1 (0.42) | ALDH1A1MAPTTSHRGPR35HTT | |
| Ammonia Solution, Strong SCHEMBL30580416 | 0.82 | CASP6 (0.43) | TDP1TSHRGPR35CASP6LMNA | |
| SCHEMBL30580417 | 0.82 | CA1 (0.38) | ALDH1A1TDP1MAPTVCAM1GPR35 | |
| Hydrochloric Acid SCHEMBL6429065 | 0.82 | CASP6 (0.43) | TDP1TSHRGPR35CASP6LMNA | |
| SCHEMBL30580418 | 0.82 | CA1 (0.38) | ALDH1A1TDP1MAPTGPR35HTT | |
| Potassium Ion SCHEMBL30721056 | 0.82 | CA1 (0.38) | ALDH1A1TDP1MAPTVCAM1GPR35 | |
| SCHEMBL12559304 | 0.82 | MAPK1 (0.41) | ALDH1A1TDP1MAPTTSHRGPR35 | |
| SCHEMBL6670434 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TDP1MAPTGPR35HTT | |
| SCHEMBL11017953 | 0.78 | CASP6 (0.36) | TDP1MAPTTSHRGPR35HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-10-06 | — | — | US | disclosed |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | disclosed |
| WO-2005007625-A2 | HETEROCYCLIC AMIDES WITH ANTI-TUBERCULOSIS ACTIVITY | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, NDUFS5 | ALDH1A1 2116/4885TDP1 4560/4885MAPT 4111/4885 |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, HDAC5 | ALDH1A1 2819/4885TDP1 4394/4885MAPT 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.