Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL19876603 | 0.85 | HSD17B10 (0.61) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL1472873 | 0.81 | OPRD1 (0.57) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL2061911 | 0.76 | PARP1 (0.89) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL27340650 | 0.76 | PARP1 (0.89) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL28132124 | 0.76 | PARP1 (0.89) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL6690447 | 0.76 | PARP1 (1.00) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL30112947 | 0.76 | PARP1 (1.00) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL1222101 | 0.76 | PARP1 (1.00) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| SCHEMBL21755166 | 0.76 | PARP1 (1.00) | POLBHSD17B10MAPTCYP3A4PARP1 | |
| Benzamide SCHEMBL1332331 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927049-B1 | LABELLED ELASTASE INHIBITORS | AMERSHAM PLC (GB) | 2005-05-11 | — | — | EP | disclosed |
| US-6375926-B1 | HUMAN LEUCOCYTE ELASTASE (HLE) INHIBITOR LABELLED WITH A DETECTABLE MOIETY WHERE THE INHIBITOR IS SYNTHETIC AND THE DETECTABLE MOIETY IS CHOSEN FROM A RADIOACTIVE ISOTOPE, A PARAMAGNETIC ION, A RADIOPAQUE COMPOUND AND AN ULTRASOUND | AMERSHAM INTERNATIONAL PLC | 2002-04-23 | — | — | US | disclosed |
| EP-0927049-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL plc (GB) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998010800-A2 | LABELLED ELASTASE INHIBITORS | AMERSHAM INTERNATIONAL PLC (GB) | 1998-03-19 | — | — | WO | disclosed |