SCHEMBL6431422

SCHEMBL6431422

Clc1cccc(CN(c2ccccc2)C2CC2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 5/20 0.52
SLC6A4 P31645 5/20 0.52
SLC6A3 Q01959 5/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
CYP2C9 P11712 2/20 0.52
CYP2C19 P33261 2/20 0.52
NOS2 P35228 1/20 0.49
SIGMAR1 Q99720 1/20 0.46
PGR P06401 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46
S1PR1 P21453 1/20 0.45
GAA P10253 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GLA P06280 1/20 0.44
MAPT P10636 1/20 0.44
HTT P42858 1/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4305010 0.90 NOS2 (0.62) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL5969506 0.84 OPRM1 (0.50) CYP2D6CYP2C9SIGMAR1PGRALDH1A1
SCHEMBL4183914 0.81 SLC6A2 (0.47) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL4306307 0.78 MEN1 (0.57) CYP2D6CYP2C9PGRKDM4EMAPT
SCHEMBL4309725 0.78 SLC6A2 (0.56) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL4311545 0.78 TACR1 (0.53) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL13681450 0.77 TAAR1 (0.51) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL4306256 0.77 SLC6A2 (0.53) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL4308562 0.77 SLC6A2 (0.60) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4
SCHEMBL8809151 0.76 AGER (0.57) SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501830-A1 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES Actelion Pharmaceuticals Ltd. (CH) 2005-02-02 EP disclosed
WO-2003093267-A1 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES ACTELION PHARMACEUTICALS LTD (CH) 2003-11-13 WO disclosed