SCHEMBL643167

SCHEMBL643167

C=CCc1ccc(C2([SiH3])CCCCO2)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.34
ALDH1A1 P00352 2/20 0.34
MAPT P10636 2/20 0.34
TP53 P04637 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
ALOX12 P18054 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP1A2 P05177 1/20 0.34
XDH P47989 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH2 P05091 1/20 0.30
GAA P10253 1/20 0.30
GABRA1 P14867 1/20 0.30
AKR1B1 P15121 1/20 0.30
HPGD P15428 1/20 0.30
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30
PPARG P37231 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28277820 0.86
SCHEMBL26131220 0.82 KCNH2 (0.31)
SCHEMBL28186420 0.82 ESR1 (0.32) ALDH1A1
SCHEMBL27514353 0.80 ESR1 (0.31) ALDH1A1
SCHEMBL5705010 0.80 ALDH1A1 (0.37) ALDH1A1
SCHEMBL2835240 0.80 KCNH2 (0.34) ALDH1A1MAPTTSHRSMN1; SMN2
SCHEMBL9005285 0.80 KCNH2 (0.31)
SCHEMBL27284604 0.80 LOXL2 (0.35)
SCHEMBL5815903 0.80 KCNH2 (0.31)
SCHEMBL2001376 0.80 KCNH2 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230296998-A1 Toner Comprising Charge Control Agent U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT 2023-09-21 US claimed
EP-4246233-A1 TONER COMPRISING CHARGE CONTROL AGENT Xerox Corporation (US) 2023-09-20 EP claimed
US-20180291299-A1 ORGANOSILOXANE COMPOSITIONS DOW SILICONES CORP (US) 2018-10-11 US claimed
US-10011801-B2 Organosiloxane compositions DOW SILICONES CORPORATION (US) 2018-07-03 US claimed
US-20160281019-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION 2016-09-29 US claimed
EP-3071678-A1 ORGANOSILOXANE COMPOSITIONS Dow Corning Corporation (US) 2016-09-28 EP claimed
WO-2015077391-A1 ORGANOSILOXANE COMPOSITIONS DOW CORNING CORPORATION (US) 2015-05-28 WO claimed
US-8377553-B2 Constrained layer damper, and related methods MATERIAL SCIENCES CORPORATION (US) 2013-02-19 US claimed
EP-2373491-A1 PRINTING METHOD, IN PARTICULAR OFFSET-PRINTING METHOD, AND SEPARATING MEANS THEREFOR WEROS Technology GmbH (DE) 2011-10-12 EP claimed
WO-2010066886-A1 PRINTING METHOD, IN PARTICULAR OFFSET-PRINTING METHOD, AND SEPARATING MEANS THEREFOR WEROS TECHNOLOGY GMBH (DE) 2010-06-17 WO claimed
US-6833422-B2 Interfacial polymerization of polycarbonates with polysiloxanes, then endcapping to form haze-free polycarbonatepolysiloxane copolymers GENERAL ELECTRIC COMPANY 2004-12-21 US claimed
WO-2004016674-A1 METHOD OF PREPARING TRANSPARENT SILICONE-CONTAINING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2004-02-26 WO claimed
EP-0557512-A1 UTILIZATION IN COSMETIC OR TOPICAL APPLICATIONS OF AN AQUEOUS DISPERSION BASED ON ORGANOPOLYSILOXANES AND A CROSSLINKED COPOLYMER OF ACRYLAMIDE/NEUTRALIZED 2-ACRYLAMIDO 2-METHYLPROPANE SULFONIC ACID. OREAL (FR) 1993-09-01 EP claimed
WO-1993005762-A1 UTILIZATION IN COSMETIC OR TOPICAL APPLICATIONS OF AN AQUEOUS DISPERSION BASED ON ORGANOPOLYSILOXANES AND A CROSSLINKED COPOLYMER OF ACRYLAMIDE/NEUTRALIZED 2-ACRYLAMIDO 2-METHYLPROPANE SULFONIC ACID L'OREAL (FR) 1993-04-01 WO claimed
US-5189102-A Oil in water repellent with improved electrical insulative properties RICOH COMPANY, LTD. (JP) 1993-02-23 US claimed
EP-0107811-B1 COLD HARDENING POLYURETHANE-FORMING FOUNDRY AGGREGATE BINDER, ITS PREPARATION AND ITS USE Hüttenes-Albertus Chemische-Werke GmbH (DE) 1986-12-10 EP claimed
US-4507408-A NONHYDROLYZING, SILANE-MODIFIED PHENOLIC RESIN HUETTENES-ALBERTUS CHEMISCHE WERKE GMBH (DE) 1985-03-26 US claimed
US-4373768-A Thermostatic fiber optic waveguides RAYCHEM CORPORATION (US) 1983-02-15 US claimed
EP-0037266-A2 Method and apparatus for controlling the temperature of or indicating the presence of a material by means of a waveguide, heat activatable articles incorporating waveguides; and novel waveguides and a method of making such waveguides RAYCHEM CORPORATION (a California corporation) (US) 1981-10-07 EP claimed
US-4220342-A Gasket having polysiloxane sealant layer containing organotitanate DANA CORPORATION (US) 1980-09-02 US claimed