Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 9/20 | 0.35 |
| ▸ | JAK1 | P23458 | 9/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPR3 | P17342 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439454 | 0.89 | GAA (0.45) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL6435667 | 0.85 | MAPT (0.42) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL6436802 | 0.82 | MAPT (0.44) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL6419799 | 0.77 | SMN1; SMN2 (0.48) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL6435103 | 0.74 | HTT (0.33) | KMT2APOLBLMNAHTTKDM4E | |
| SCHEMBL6435528 | 0.72 | HTT (0.32) | HTT | |
| SCHEMBL3050610 | 0.71 | SMN1; SMN2 (0.67) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL17249530 | 0.68 | GAA (0.66) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL8266095 | 0.68 | SMN1; SMN2 (0.59) | GAARECQLSMN1; SMN2TP53MAPT | |
| SCHEMBL21497112 | 0.68 | SMN1; SMN2 (0.56) | GAARECQLSMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |